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KMID : 0545119950050020105
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Journal of Microbiology and Biotechnology
1995 Volume.5 No. 2 p.105 ~ p.109
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Detection of Anticancer Activity from the Root of Angelica gigas in Vitro
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AHN, KYUNG SEOP
SIM, WOONG SEOP/KIM, IK HWAN
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Abstract
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Anticancer activity of a fraction of the ethanol extract from the root of Korean angelica (Angelica gigas Nakai) was recognized in human cancer cell lines HeLa S_3 K-562, and Hep G_2. The extract blocked the phorbol ester-inducing megakaryocytic differentiation of K-562 cells, which indicated the modification of protein kinase C (PKC) activity. In vitro assay showed the activation of PKC by the extract. An effective fraction of the Angelica gigas extract, of which R_f value was 0.64 in a thin layer chromatography, was a different component from those of European angelicas. The ED_50 value of the fraction was 8, 9, and 16 ㎍/㎖ against HeLa S_3 Hep G_2 and K-562 cells, respectively, while the fraction showed higher ED_50 values against normal cell lines.
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KEYWORD
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